Dataset Information

Adipocytokines and Insulin Resistance: Their Role as Benign Breast Disease and Breast Cancer Risk Factors in a High-Prevalence Overweight-Obesity Group of Women over 40 Years Old.

ABSTRACT: Insulin levels, adipocytokines, and inflammatory mediators trigger benign breast disease (BBD) and breast cancer (BC). The relationship between serum adipocytokines levels, overweight-obesity, metabolic disturbs, and BC is unclear.

Methods

To analyze the serum levels of the adipocytokines, insulin, and the HOMA IR in women without breast disease, with BBD or BC, and the role of these as risk factors for benign breast disease or breast cancer.

Results

Adipsin values > 0.91 and visfatin levels > 1.18 ng/mL represent a risk factor to develop BBD in NBD lean women (OR = 18; and OR = 12). Data in overweight-obese women groups confirm the observation due to insulin levels > 2.6 mU/mL and HOMA IR > 0.78, with OR = 60.2 and 18, respectively; adipsin OR = 26.4, visfatin OR = 12. Breast cancer risk showed a similar behavior: Adipsin risk, adjusted by insulin and visfatin OR = 56 or HOMA IR and visfatin OR = 22.7.

Conclusion

Adipose tissue is crucial for premalignant and malignant tissue transformation in women with overweight-obesity. The adipocyte-breast epithelium interaction could trigger a malignant transformation in a continuum, starting with BBD as premalignant disease, especially in overweight-obese women.

SUBMITTER: Sat-Munoz D

PROVIDER: S-EPMC9140417 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Adipocytokines and Insulin Resistance: Their Role as Benign Breast Disease and Breast Cancer Risk Factors in a High-Prevalence Overweight-Obesity Group of Women over 40 Years Old.

Sat-Muñoz Daniel D Martínez-Herrera Brenda-Eugenia BE Quiroga-Morales Luis-Aarón LA Trujillo-Hernández Benjamín B González-Rodríguez Javier-Andrés JA Gutiérrez-Rodríguez Leonardo-Xicotencatl LX Leal-Cortés Caridad-Aurea CA Portilla-de-Buen Eliseo E Rubio-Jurado Benjamín B Salazar-Páramo Mario M Gómez-Sánchez Eduardo E Delgadillo-Cristerna Raúl R Carrillo-Nuñez Gabriela-Guadalupe GG Nava-Zavala Arnulfo-Hernán AH Balderas-Peña Luz-Ma-Adriana LM

International journal of environmental research and public health 20220517 10

Insulin levels, adipocytokines, and inflammatory mediators trigger benign breast disease (BBD) and breast cancer (BC). The relationship between serum adipocytokines levels, overweight-obesity, metabolic disturbs, and BC is unclear. Methods: To analyze the serum levels of the adipocytokines, insulin, and the HOMA IR in women without breast disease, with BBD or BC, and the role of these as risk factors for benign breast disease or breast cancer. Results: Adipsin values > 0.91 and visfatin levels > ...[more]

PMID: 35627631

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Dataset Information

Adipocytokines and Insulin Resistance: Their Role as Benign Breast Disease and Breast Cancer Risk Factors in a High-Prevalence Overweight-Obesity Group of Women over 40 Years Old.

Methods

Results

Conclusion

Publications

Adipocytokines and Insulin Resistance: Their Role as Benign Breast Disease and Breast Cancer Risk Factors in a High-Prevalence Overweight-Obesity Group of Women over 40 Years Old.

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