Quest for Quality in Translational Stroke Research-A New Dawn for Neuroprotection?

ABSTRACT: Despite tremendous progress in modern-day stroke therapy, ischemic stroke remains a disease associated with a high socioeconomic burden in industrialized countries. In light of demographic change, these health care costs are expected to increase even further. The current causal therapeutic treatment paradigms focus on successful thrombolysis or thrombectomy, but only a fraction of patients qualify for these recanalization therapies because of therapeutic time window restrictions or contraindications. Hence, adjuvant therapeutic concepts such as neuroprotection are urgently needed. A bench-to-bedside transfer of neuroprotective approaches under stroke conditions, however, has not been established after more than twenty years of research, albeit a great many data have demonstrated several ne

SUBMITTER: Haupt M 

PROVIDER: S-EPMC9140731 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature