MicroRNA Expression Profiling in Age-Dependent Renal Impairment.

ABSTRACT:

Background

Age-dependent renal impairment contributes to renal dysfunction in both the general population and young and middle-aged patients with renal diseases. Pathological changes in age-dependent renal impairment include glomerulosclerosis and tubulointerstitial fibrosis. The molecules involved in age-dependent renal impairment are not fully elucidated. MicroRNA (miRNA) species were reported to modulate various renal diseases, but the miRNA species involved in age-dependent renal impairment are unclear. Here, we investigated miRNAs in age-dependent renal impairment, and we evaluated their potential as biomarkers and therapeutic targets.

Methods

We conducted an initial microarray profiling analysis to screen miRNAs whose expression levels changed in kidneys of senescence-

SUBMITTER: Yanai K 

PROVIDER: S-EPMC9140741 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature