The Mechanisms of Thin Filament Assembly and Length Regulation in Muscles.

ABSTRACT: The actin containing tropomyosin and troponin decorated thin filaments form one of the crucial components of the contractile apparatus in muscles. The thin filaments are organized into densely packed lattices interdigitated with myosin-based thick filaments. The crossbridge interactions between these myofilaments drive muscle contraction, and the degree of myofilament overlap is a key factor of contractile force determination. As such, the optimal length of the thin filaments is critical for efficient activity, therefore, this parameter is precisely controlled according to the workload of a given muscle. Thin filament length is thought to be regulated by two major, but only partially understood mechanisms: it is set by (i) factors that mediate the assembly of filaments from monomers and ca

SUBMITTER: Szikora S 

PROVIDER: S-EPMC9140763 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature