Smart Methylcellulose Hydrogels for pH-Triggered Delivery of Silver Nanoparticles.

ABSTRACT: Infection is a severe complication in chronic wounds, often leading to morbidity or mortality. Current treatments rely on dressings, which frequently contain silver as a broad-spectrum antibacterial agent, although improper dosing can result in severe side effects. This work proposes a novel methylcellulose (MC)-based hydrogel designed for the topical release of silver nanoparticles (AgNPs) via an intelligent mechanism activated by the pH variations in infected wounds. A preliminary optimization of the physicochemical and rheological properties of MC hydrogels allowed defining the optimal processing conditions in terms of crosslinker (citric acid) concentration, crosslinking time, and temperature. MC/AgNPs nanocomposite hydrogels were obtained via an in situ synthesis process, exploiting M

SUBMITTER: Bonetti L 

PROVIDER: S-EPMC9140787 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature