Gut Microbiota as a Potential Predictive Biomarker in Relapsing-Remitting Multiple Sclerosis.

ABSTRACT:

Background

The influence of the microbiome on neurological diseases has been studied for years. Recent findings have shown a different composition of gut microbiota detected in patients with multiple sclerosis (MS). The role of this dysbiosis is still unknown.

Objective

We analyzed the gut microbiota of 15 patients with active relapsing-remitting multiple sclerosis (RRMS), comparing with diet-matched healthy controls.

Method

To determine the composition of the gut microbiota, we performed high-throughput sequencing of the 16S ribosomal RNA gene. The specific amplified sequences were in the V3 and V4 regions of the 16S ribosomal RNA gene.

Results

The gut microbiota of RRMS patients differed from healthy controls in the levels of the Lachnospiraceae, Ez

SUBMITTER: Navarro-Lopez V 

PROVIDER: S-EPMC9140870 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature