Amyloidogenic Peptides: New Class of Antimicrobial Peptides with the Novel Mechanism of Activity.

ABSTRACT: Antibiotic-resistant bacteria are recognized as one of the leading causes of death in the world. We proposed and successfully tested peptides with a new mechanism of antimicrobial action "protein silencing" based on directed co-aggregation. The amyloidogenic antimicrobial peptide (AAMP) interacts with the target protein of model or pathogenic bacteria and forms aggregates, thereby knocking out the protein from its working condition. In this review, we consider antimicrobial effects of the designed peptides on two model organisms, E. coli and T. thermophilus, and two pathogenic organisms, P. aeruginosa and S. aureus. We compare the amino acid composition of proteomes and especially S1 ribosomal proteins. Since this protein is inherent only in bacterial cells, it

SUBMITTER: Galzitskaya OV 

PROVIDER: S-EPMC9140876 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature