Concussion-Associated Polygenic Profiles of Elite Male Rugby Athletes.

ABSTRACT: Due to the high-velocity collision-based nature of elite rugby league and union, the risk of sustaining a concussion is high. Occurrence of and outcomes following a concussion are probably affected by the interaction of multiple genes in a polygenic manner. This study investigated whether suspected concussion-associated polygenic profiles of elite rugby athletes differed from non-athletes and between rugby union forwards and backs. We hypothesised that a total genotype score (TGS) using eight concussion-associated polymorphisms would be higher in elite rugby athletes than non-athletes, indicating selection for protection against incurring or suffering prolonged effects of, concussion in the relatively high-risk environment of competitive rugby. In addition, multifactor dimensionality reduc

SUBMITTER: Antrobus MR 

PROVIDER: S-EPMC9141383 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature