Regulation of Neuroinflammatory Signaling by PPARγ Agonist in Mouse Model of Diabetes.

ABSTRACT: Many relevant studies, as well as clinical practice, confirm that untreated diabetes predisposes the development of neuroinflammation and cognitive impairment. Having regard for the fact that PPARγ are widely distributed in the brain and PPARγ ligands may regulate the inflammatory process, the anti-inflammatory potential of the PPARγ agonist, pioglitazone, was assessed in a mouse model of neuroinflammation related with diabetes. In this regard, the biochemical and molecular indicators of neuroinflammation were determined in the hippocampus and prefrontal cortex of diabetes mice. The levels of cytokines (IL-1β, IL-6, and TNF) and the expression of genes (Tnfrsf1a and Cav1) were measured. In addition, behavioral tests such as the open field test, the

SUBMITTER: Piatkowska-Chmiel I 

PROVIDER: S-EPMC9141386 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature