Recent Advances in Understanding the Structures of Translesion Synthesis DNA Polymerases.

ABSTRACT: DNA damage in the template strand causes replication forks to stall because replicative DNA polymerases are unable to efficiently incorporate nucleotides opposite template DNA lesions. To overcome these replication blocks, cells are equipped with multiple translesion synthesis polymerases that have evolved specifically to incorporate nucleotides opposite DNA lesions. Over the past two decades, X-ray crystallography has provided a wealth of information about the structures and mechanisms of translesion synthesis polymerases. This approach, however, has been limited to ground state structures of these polymerases bound to DNA and nucleotide substrates. Three recent methodological developments have extended our understanding of the structures and mechanisms of these polymerases. These include

SUBMITTER: Ling JA 

PROVIDER: S-EPMC9141541 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature