Physiological Role of ATPase for GABA_A Receptor Resensitization.

ABSTRACT: γ-Aminobutyric acid type A receptors (GABA_ARs) mediate primarily inhibitory synaptic transmission in the central nervous system. Following fast-paced activation, which provides the selective flow of mainly chloride (Cl^-) and less bicarbonate (HCO₃^-) ions via the pore, these receptors undergo desensitization that is paradoxically prevented by the process of their recovery, referred to as resensitization. To clarify the mechanism of resensitization, we used the cortical synaptoneurosomes from the rat brain and HEK 293FT cells. Here, we describe the effect of γ-phosphate analogues (γPAs) that mimic various states of ATP hydrolysis on GABA_AR-mediated Cl^- and HCO₃^- fluxes in response to the first and repeate

SUBMITTER: Menzikov SA 

PROVIDER: S-EPMC9141714 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature