Novel Thermostable Heparinase Based on the Genome of Bacteroides Isolated from Human Gut Microbiota.

ABSTRACT: Among the nutrients available to the human gut microbiota, the complex carbohydrates and glycosaminoglycans are important sources of carbon for some of the species of human gut microbiota. Glycosaminoglycan (heparin) from the host is a highly preferred carbohydrate for Bacteroides. To explore how gut microbiota can effectively use heparin as a carbon source for growth, we conducted a screening of the Carbohydrate-Active enzymes (CAZymes) database for lytic enzymes of the PL13 family and Research Center of Food Biotechnology at School of Food Science and Technology of Jiangnan University database of Bacteroides to identify novel glycosaminoglycan-degrading bacterial strains. Four Bacteroides species (Bacteroides eggerthii, Bacteroides clarus, Bacteroide

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9141863 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature