The Astonishing Large Family of HSP40/DnaJ Proteins Existing in Leishmania.

ABSTRACT: Abrupt environmental changes are faced by Leishmania parasites during transmission from a poikilothermic insect vector to a warm-blooded host. Adaptation to harsh environmental conditions, such as nutrient deprivation, hypoxia, oxidative stress and heat shock needs to be accomplished by rapid reconfiguration of gene expression and remodeling of protein interaction networks. Chaperones play a central role in the maintenance of cellular homeostasis, and they are responsible for crucial tasks such as correct folding of nascent proteins, protein translocation across different subcellular compartments, avoiding protein aggregates and elimination of damaged proteins. Nearly one percent of the gene content in the Leishmania genome corresponds to members of the HSP40 family, a group

SUBMITTER: Solana JC 

PROVIDER: S-EPMC9141911 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature