Identification of the circRNA-miRNA-mRNA Prognostic Regulatory Network in Lung Adenocarcinoma.

ABSTRACT:

Background

Numerous studies have identified that circular RNAs (circRNAs) can serve as competing endogenous RNAs (ceRNAs) to regulate tumor progression. However, there are still a large number of circRNAs to be deciphered.

Objective

The purpose of this study was to reveal novel circRNAs and their potential role in lung adenocarcinoma (LUAD).

Methods

To unveil LUAD-related circRNAs, microRNA (miRNAs), and messenger RNA (mRNA) and elucidate their possible molecular mechanisms, we employed a strategy combining extensive data mining and bioinformatics methods. According to the results of bioinformatics workflow analysis, a novel circRNA-miRNA-mRNA network was constructed.

Results

Ten circRNAs with different expressions were acquired from four Gene Expression Omnibu

SUBMITTER: Ma Y 

PROVIDER: S-EPMC9141977 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature