Higher-order olfactory neurons in the lateral horn support odor valence and odor identity coding in Drosophila.

ABSTRACT: Understanding neuronal representations of odor-evoked activities and their progressive transformation from the sensory level to higher brain centers features one of the major aims in olfactory neuroscience. Here, we investigated how odor information is transformed and represented in higher-order neurons of the lateral horn, one of the higher olfactory centers implicated in determining innate behavior, using Drosophila melanogaster. We focused on a subset of third-order glutamatergic lateral horn neurons (LHNs) and characterized their odor coding properties in relation to their presynaptic partner neurons, the projection neurons (PNs) by two-photon functional imaging. We show that odors evoke reproducible, stereotypic, and odor-specific response patterns in LHNs. Notably, odor-evoked

SUBMITTER: Das Chakraborty S 

PROVIDER: S-EPMC9142144 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature