An MRI method for parcellating the human striatum into matrix and striosome compartments in vivo.

ABSTRACT: The mammalian striatum is comprised of intermingled tissue compartments, matrix and striosome. Though indistinguishable by routine histological techniques, matrix and striosome have distinct embryologic origins, afferent/efferent connections, surface protein expression, intra-striatal location, susceptibilities to injury, and functional roles in a range of animal behaviors. Distinguishing the compartments previously required post-mortem tissue and/or genetic manipulation; we aimed to identify matrix/striosome non-invasively in living humans. We used diffusion MRI (probabilistic tractography) to identify human striatal voxels with connectivity biased towards matrix-favoring or striosome-favoring regions (determined by prior animal tract-tracing studies). Segmented striatal compartments repl

SUBMITTER: Waugh JL 

PROVIDER: S-EPMC9142299 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature