Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC9142503 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Li Feiran F Chen Yu Y Qi Qi Q Wang Yanyan Y Yuan Le L Huang Mingtao M Elsemman Ibrahim E IE Feizi Amir A Kerkhoven Eduard J EJ Nielsen Jens J
Nature communications 20220527 1
Eukaryotic cells are used as cell factories to produce and secrete multitudes of recombinant pharmaceutical proteins, including several of the current top-selling drugs. Due to the essential role and complexity of the secretory pathway, improvement for recombinant protein production through metabolic engineering has traditionally been relatively ad-hoc; and a more systematic approach is required to generate novel design principles. Here, we present the proteome-constrained genome-scale protein s ...[more]