A global method for fast simulations of molecular dynamics in multiscale agent-based models of biological tissues.

ABSTRACT: Agent-based models (ABMs) are a natural platform for capturing the multiple time and spatial scales in biological processes. However, these models are computationally expensive, especially when including molecular-level effects. The traditional approach to simulating this type of multiscale ABM is to solve a system of ordinary differential equations for the molecular events per cell. This significantly adds to the computational cost of simulations as the number of agents grows, which contributes to many ABMs being limited to around 105 cells. We propose an approach that requires the same computational time independent of the number of agents. This speeds up the entire simulation by orders of magnitude, allowing for more thorough explorations of ABMs with even larger numbers of agents. We u

SUBMITTER: Bergman D 

PROVIDER: S-EPMC9142654 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature