Dataset Information

Burden of chronic hepatitis B and C infections in 2015 and future trends in Japan: A simulation study.

ABSTRACT:

Background

Determining the number of chronic hepatitis B (HBV) and C virus (HCV) infections is essential to assess the progress towards the World Health Organization 2030 viral hepatitis elimination goals. Using data from the Japanese National Database (NDB), we calculated the number of chronic HBV and HCV infections in 2015 and predicted the trend until 2035.

Methods

NDB and first-time blood donors data were used to calculate the number of chronic HBV and HCV infections in 2015. A Markov simulation was applied to predict chronic infections until 2035 using transition probabilities calculated from NDB data.

Findings

The total number of chronic HBV and HCV infections in 2015 in Japan was 1,905,187-2,490,873 (HCV:877,841-1,302,179, HBV:1,027,346-1,188,694), of which 923,661-1,509,347 were undiagnosed or diagnosed but not linked to care ("not engaged in care"), and 981,526 were engaged in care. Chronic HBV and HCV infections are expected to be 923,313-1,304,598 in 2030, and 739,118-1,045,884 in 2035. Compared to 2015, by 2035, the number of persons with HCV not engaged in care will decline by 59·8 - 76·1% and 86·5% for patients in care. For HBV, a 47·3 - 49·3% decrease is expected for persons not engaged in care and a decline of 26·0% for patients engaged in care.

Interpretation

Although the burden of HBV and HCV is expected to decrease by 2035, challenges in controlling hepatitis remain. Improved and innovative screening strategies with linkage to care for HCV cases, and a functional cure for HBV are needed.

Funding

Japan Ministry of Health, Labour and Welfare.

SUBMITTER: Tanaka J

PROVIDER: S-EPMC9142742 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Burden of chronic hepatitis B and C infections in 2015 and future trends in Japan: A simulation study.

Tanaka Junko J Kurisu Akemi A Ohara Masatsugu M Ouoba Serge S Ohisa Masayuki M Sugiyama Aya A Wang Michelle L ML Hiebert Lindsey L Kanto Tatsuya T Akita Tomoyuki T

The Lancet regional health. Western Pacific 20220316

<h4>Background</h4>Determining the number of chronic hepatitis B (HBV) and C virus (HCV) infections is essential to assess the progress towards the World Health Organization 2030 viral hepatitis elimination goals. Using data from the Japanese National Database (NDB), we calculated the number of chronic HBV and HCV infections in 2015 and predicted the trend until 2035.<h4>Methods</h4>NDB and first-time blood donors data were used to calculate the number of chronic HBV and HCV infections in 2015. ...[more]

PMID: 35637862

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Dataset Information

Burden of chronic hepatitis B and C infections in 2015 and future trends in Japan: A simulation study.

Background

Methods

Findings

Interpretation

Funding

Publications

Burden of chronic hepatitis B and C infections in 2015 and future trends in Japan: A simulation study.

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