Triiodothyronine (T3), inflammation and mortality risk in patients with acute myocardial infarction.

ABSTRACT:

Objectives

To study the relationship between serum-free T3 (FT3), C-reactive protein (CRP) and all-cause mortality in patients with acute myocardial infarction (AMI).

Design

Prospective multicentre longitudinal cohort study.

Methods

Between December 2014 and December 2016, thyroid function and CRP were analysed in AMI (both ST-elevation (STEMI) and non-ST-elevation) patients from the Thyroxine in Acute Myocardial Infarction study. The relationship of FT3 and CRP at baseline with all-cause mortality up to June 2020 was assessed. Mediation analysis was performed to evaluate if CRP mediated the relationship between FT3 and mortality.

Results

In 1919 AMI patients (29.2% women, mean (s.d.) age: 64.2 (12.1) years and 48.7% STEMI) followed over a median (interquartile

SUBMITTER: Razvi S 

PROVIDER: S-EPMC9142797 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature