Classification of maternal thyroid function in early pregnancy using repeated blood samples.

ABSTRACT:

Objective

The assessment of maternal thyroid function in early pregnancy is debated. It is well-established that pregnancy-specific reference ranges preferably should be used. We speculated if the use of repeated blood samples drawn in early pregnancy would influence the classification of maternal thyroid function.

Methods

Pregnant women with repeated early pregnancy blood samples were identified in the North Denmark Region Pregnancy Cohort. Each sample was used for the measurement of TSH, free T4 (fT4), thyroid peroxidase antibodies (TPO-Ab), and thyroglobulin antibodies (Tg-Ab) (ADVIA Centaur XPT, Siemens Healthineers). Method- and pregnancy week-specific reference ranges were used for the classification of maternal thyroid function.

Results

Among 1466 pregnancies i

SUBMITTER: Knosgaard L 

PROVIDER: S-EPMC9142809 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature