Effects of Acute and Chronic Resistance Exercise on the Skeletal Muscle Metabolome.

ABSTRACT: Resistance training promotes metabolic health and stimulates muscle hypertrophy, but the precise routes by which resistance exercise (RE) conveys these health benefits are largely unknown.

Aim

To investigate how acute RE affects human skeletal muscle metabolism.

Methods

We collected vastus lateralis biopsies from six healthy male untrained volunteers at rest, before the first of 13 RE training sessions, and 45 min after the first and last bouts of RE. Biopsies were analysed using untargeted mass spectrometry-based metabolomics.

Results

We measured 617 metabolites covering a broad range of metabolic pathways. In the untrained state RE altered 33 metabolites, including increased 3-methylhistidine and N-lactoylvaline, suggesting increased protein breakdown, as well as met

SUBMITTER: Gehlert S 

PROVIDER: S-EPMC9142957 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature