Increase in Mitochondrial D-Loop Region Methylation Levels in Mild Cognitive Impairment Individuals.

ABSTRACT: Methylation levels of the mitochondrial displacement loop (D-loop) region have been reported to be altered in the brain and blood of Alzheimer's disease (AD) patients. Moreover, a dynamic D-loop methylation pattern was observed in the brain of transgenic AD mice along with disease progression. However, investigations on the blood cells of AD patients in the prodromal phases of the disease have not been performed so far. The aim of this study was to analyze D-loop methylation levels by means of the MS-HRM technique in the peripheral blood cells of 14 mild cognitive impairment (MCI) patients, 18 early stage AD patients, 70 advanced stage AD patients, and 105 healthy control subjects. We found higher D-loop methylation levels in MCI patients than in control subjects and AD patients. Moreover,

SUBMITTER: Stoccoro A 

PROVIDER: S-EPMC9142993 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature