Zinc-Containing Sol-Gel Glass Nanoparticles to Deliver Therapeutic Ions.

ABSTRACT: Zn-containing dense monodispersed bioactive glass nanoparticles (Zn-BAGNPs) have been developed to deliver therapeutic inorganic trace elements, including Si, Ca, Sr, and Zn, to the cells through the degradation process, as delivery carriers for stimulating bone regeneration because of their capacity to induce osteogenic differentiation. The sol-gel-derived dense silica nanoparticles (SiO₂-NPs) were first synthesized using the modified Stöber method, prior to incorporating therapeutic cations through the heat treatment process. The successfully synthesized monodispersed Zn-BAGNPs (diameter of 130 ± 20 nm) were homogeneous in size with spherical morphology. Ca, Sr and Zn were incorporated through the two-step post-functionalization process, with the nominal ZnO ratio between 0 an

SUBMITTER: Thanasrisuebwong P 

PROVIDER: S-EPMC9143105 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature