A Non-Invasive Neonatal Signature Predicts Later Development of Atopic Diseases.

ABSTRACT: Background: Preterm birth is a major cause of morbidity and mortality in infants and children. Non-invasive methods for screening the neonatal immune status are lacking. Archaea, a prokaryotic life domain, comprise methanogenic species that are part of the neonatal human microbiota and contribute to early immune imprinting. However, they have not yet been characterized in preterm neonates. Objective: To characterize the gut immunological and methanogenic Archaeal (MA) signature in preterm neonates, using the presence or absence of atopic conditions at the age of one year as a clinical endpoint. Methods: Meconium and stool were collected from preterm neonates and used to develop a standardized stool preparation method for the assessment of mediators and cytokines and ch

SUBMITTER: Sereme Y 

PROVIDER: S-EPMC9143112 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature