Nitric Oxide Mobilizes Intracellular Zn²⁺ via the GC/cGMP/PKG Signaling Pathway and Stimulates Adipocyte Differentiation.

ABSTRACT: Plasma and tissue zinc ion levels are associated with the development of obesity. Previous studies have suggested that zinc ions may regulate adipocyte metabolism and that nitric oxide (NO) plays a pivotal role in the regulation of adipocyte physiology. Our previous study showed that chronic NO deficiency causes a significant decrease in adipose tissue mass in rats. Studies also suggested that zinc ions play an important modulatory role in regulating NO function. This study aims to explore the role of zinc ions in NO-regulated adipocyte differentiation. We hypothesized that NO could increase intracellular Zn²⁺ level and then stimulate adipocyte differentiation. ZnCl₂ and the NO donor, NONOate, were used to explore the effects of Zn²⁺ and NO on adipocyte dif

SUBMITTER: Chen CW 

PROVIDER: S-EPMC9143299 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature