Twelve-Month Longitudinal Serology in SARS-CoV-2 Naive and Experienced Vaccine Recipients and Unvaccinated COVID-19-Infected Individuals.

ABSTRACT: Longitudinal data comparing SARS-CoV-2 serology in individuals following infection and vaccination over 12 months are limited. This study compared the magnitude, decay, and variability in serum IgG, IgA, and neutralizing activity induced by natural infection (n = 218) or mRNA vaccination in SARS-CoV-2 naïve (n = 143) or experienced (n = 122) individuals over time using enzyme-linked immunosorbent assays and an in vitro virus neutralization assay. Serological responses were found to be highly variable after natural infection compared with vaccination but durable through 12 months. Antibody levels in vaccinated, SARS-CoV-2 naïve individuals peaked by 1 month then declined through 9 months, culminating in non-detectable SARS-CoV-2-specific serum IgA. Individuals with both

SUBMITTER: Congrave-Wilson Z 

PROVIDER: S-EPMC9143304 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature