Clinical Efficacy of Melon GliSODin^® for the Treatment of Aging-Related Dysfunction in Motor Organs-A Double Blind, Randomized Placebo-Controlled Study.

ABSTRACT:

Background

Locomotive syndrome is a concept proposed in Japan involving decreased mobility due to osteoarthritis, osteoporosis, and sarcopenia. This double-blind, randomized study aimed to investigate the effects of superoxide dismutase (SOD)-rich melon extract (Melon GliSODin^®) on locomotive syndrome.

Methods

For 6 months, we administered oral Melon GliSODin^® (500.4 mg/day) or a placebo to 24 and 22 women, respectively (aged 50-80 years), with knee or lower back discomfort or pain. Using baseline and 6-month data, changes in the Verbal Rating Scale and in subjective symptoms (determined using the Japanese Knee Osteoarthritis Measure, Locomo 25, the Roland-Morris Disability questionnaire, and the Chalder Fatigue Scale) were assessed, along with various

SUBMITTER: Koike M 

PROVIDER: S-EPMC9143343 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature