Mechanisms of Inhibition of Quorum Sensing as an Alternative for the Control of E. coli and Salmonella.

ABSTRACT: Quorum sensing (QS) is a process of cell-cell communication for bacteria such as E. coli and Salmonella that cause foodborne diseases, with the production, release, and detection of autoinducer (AI) molecules that participate in the regulation of virulence genes. All of these proteins are useful in coordinating collective behavior, the expression of virulence factors, and the pathogenicity of Gram-negative bacteria. In this work, we review the natural or synthetic inhibitor molecules of QS that inactivate the autoinducer and block QS regulatory proteins in E. coli and Salmonella. Furthermore, we describe mechanisms of QS inhibitors (QSIs) that act as competitive inhibitors, being a useful tool for preventing virulence gene expression through the downregulation o

SUBMITTER: Escobar-Mucino E 

PROVIDER: S-EPMC9143355 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature