Implication of microRNAs in Carcinogenesis with Emphasis on Hematological Malignancies and Clinical Translation.

ABSTRACT: MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs, that are involved in the multistep process of carcinogenesis, contributing to all established hallmarks of cancer. In this review, implications of miRNAs in hematological malignancies and their clinical utilization fields are discussed. As components of the complex regulatory network of gene expression, influenced by the tissue microenvironment and epigenetic modifiers, miRNAs are "micromanagers" of all physiological processes including the regulation of hematopoiesis and metabolic pathways. Dysregulated miRNA expression levels contribute to both the initiation and progression of acute leukemias, the metabolic reprogramming of malignantly transformed hematopoietic precursors, and to the development of chemoresistance. S

SUBMITTER: Gaal Z 

PROVIDER: S-EPMC9143361 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature