Development and Scalable Production of Newcastle Disease Virus-Vectored Vaccines for Human and Veterinary Use.

ABSTRACT: The COVID-19 pandemic has highlighted the need for efficient vaccine platforms that can rapidly be developed and manufactured on a large scale to immunize the population against emerging viruses. Viral-vectored vaccines are prominent vaccine platforms that have been approved for use against the Ebola virus and SARS-CoV-2. The Newcastle Disease Virus is a promising viral vector, as an avian paramyxovirus that infects poultry but is safe for use in humans and other animals. NDV has been extensively studied not only as an oncolytic virus but also a vector for human and veterinary vaccines, with currently ongoing clinical trials for use against SARS-CoV-2. However, there is a gap in NDV research when it comes to process development and scalable manufacturing, which are critical for future appr

SUBMITTER: Fulber JPC 

PROVIDER: S-EPMC9143368 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature