First-Void Urine Microbiome in Women with Chlamydia trachomatis Infection.

ABSTRACT:

Background

Chlamydia trachomatis (CT) is the agent of the most common bacterial sexually transmitted infection worldwide. Until now, little information is available about the microbial composition of urine samples during CT urethritis. Therefore, in this study, we characterized the microbiome and metabolome profiles of first-void urines in a cohort of women with CT urethral infection attending an STI clinic.

Methods

Based on CT positivity by nucleic acid amplification techniques on urine samples, the enrolled women were divided into two groups, i.e., "CT-negative" (n = 21) and "CT-positive" (n = 11). Urine samples were employed for (i) the microbiome profile analysis by means of 16s rRNA gene sequencing and (ii) the metabolome analysis by ¹H-N

SUBMITTER: Gaspari V 

PROVIDER: S-EPMC9143427 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature