An Unprecedented Number of Cytochrome P450s Are Involved in Secondary Metabolism in Salinispora Species.

ABSTRACT: Cytochrome P450 monooxygenases (CYPs/P450s) are heme thiolate proteins present in species across the biological kingdoms. By virtue of their broad substrate promiscuity and regio- and stereo-selectivity, these enzymes enhance or attribute diversity to secondary metabolites. Actinomycetes species are well-known producers of secondary metabolites, especially Salinispora species. Despite the importance of P450s, a comprehensive comparative analysis of P450s and their role in secondary metabolism in Salinispora species is not reported. We therefore analyzed P450s in 126 strains from three different species Salinispora arenicola, S. pacifica, and S. tropica. The study revealed the presence of 2643 P450s that can be grouped into 45 families and 103 subfamilies.

SUBMITTER: Malinga NA 

PROVIDER: S-EPMC9143469 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature