Comparison of Glycemic Variability and Hypoglycemic Events in Hospitalized Older Adults Treated with Basal Insulin plus Vildagliptin and Basal-Bolus Insulin Regimen: A Prospective Randomized Study.

ABSTRACT:

Background

The basal-bolus insulin regimen is recommended in hospitalized patients with diabetes mellitus (DM), but has an increased risk of hypoglycemia. We aimed to compare dipeptidyl peptidase 4 inhibitors (DPP4-i) and basal-bolus insulin glycemic outcomes in hospitalized type 2 DM patients.

Methods and patients

Our prospective randomized study included 102 elderly T2DM patients (82 ± 9 years, HbA1c 6.6% ± 1.9). Glycemic control: A variability coefficient assessed by continuous glucose monitoring (Free Style^® sensor), mean insulin dose and hypoglycemia rates obtained with the two treatments were analyzed.

Results

No differences were found between groups in glycemic control (mean daily glycemia during the first 10 days: 152.6 ± 38.5 vs. 154.2 ± 26.3 mg/dL

SUBMITTER: Batule S 

PROVIDER: S-EPMC9143484 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature