Hydrophilic CO-Releasing Material of PEGlyated Ruthenium Carbonyl Complex.

ABSTRACT: The poor water-solubility and instability of Ru(II) carbonyl complex hamper the therapeutic application as CO releasing materials (CO-RMs). To enhance the hydrophilicity and bio-utility of CO, a robust Ru(I) carbonyl sawhorse skeleton was grafted with water-soluble PEGylated sidearm. In this case, 12 PEGylated sawhorse Ru₂(CO)₄ complexes were prepared with satisfactory yields and characterized by IR and ¹H- and ¹³C- NMR. X-ray diffraction analysis of CO-RM 8, 13 and 14 revealed the featured diruthenium sawhorse skeleton and PEGylated axial ligands. The flask-shaking method measures the water-solubility of CO-RMs, indicating that both bridging carboxylate ligands and PEGlyated axial ligands regulate the hydrophilicity of these

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9143562 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature