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The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity.

ABSTRACT: In our current investigation, 37 constituents (1-37), including 11 megastigmanes (1-11), 17 flavonoids (12-28) and 9 phenylpropanoids (29-37), were isolated from a 70%-EtOH extract of Diaphragma juglandis Fructus. Among them, compounds 1-3, 12 and 29 were new compounds and their structures were elucidated on the basis of physicochemical evidence and meticulous spectroscopic analysis (NMR, HRESIMS and CD). Compounds 13, 16, 21 and 28 showed moderate inhibitory effect on α-glycosidase inhibitory activities, with IC₅₀ values being in the range of 29.47-54.82 µM and stronger than the positive control (acarbose, 60.01 ± 4.82 µM).

SUBMITTER: Tan J

PROVIDER: S-EPMC9143591 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity.

Tan Jinyan J Cheng Yangang Y Wang Shihui S Li Jianli J Ren Haiqin H Qiao Yuanbiao Y Li Qingshan Q Wang Yingli Y

Molecules (Basel, Switzerland) 20220510 10

In our current investigation, 37 constituents (1-37), including 11 megastigmanes (1-11), 17 flavonoids (12-28) and 9 phenylpropanoids (29-37), were isolated from a 70%-EtOH extract of Diaphragma juglandis Fructus. Among them, compounds 1-3, 12 and 29 were new compounds and their structures were elucidated on the basis of physicochemical evidence and meticulous spectroscopic analysis (NMR, HRESIMS and CD). Compoun ...[more]

PMID: 35630524

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Dataset Information

The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity.

Publications

The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity.

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