Discovery of Natural Lead Compound from Dendrobium sp. against SARS-CoV-2 Infection.

ABSTRACT: Since the pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in December 2019, the infection cases have quickly increased by more than 511 million people. The long epidemic outbreak over 28 months has affected health and economies worldwide. An alternative medicine appears to be one choice to alleviate symptoms and reduce mortality during drug shortages. Dendrobium extract is one of the traditional medicines used for COVID-19 infection. Several compounds in Dendrobium sp. had been reported to exert pharmacological activities to treat common COVID-19-related symptoms. Herein, in silico screening of 83 compounds from Dendrobium sp. by using the SARS-CoV-2 spike protein receptor-binding domain (RBD) as a drug target was performed in searching for a new

SUBMITTER: Jiaranaikulwanitch J 

PROVIDER: S-EPMC9143658 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature