IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making.

ABSTRACT: During the past few decades, the science of toxicology has been undergoing a transformation from observational to predictive science. New approach methodologies (NAMs), including in vitro assays, in silico models, read-across, and in vitro to in vivo extrapolation (IVIVE), are being developed to reduce, refine, or replace whole animal testing, encouraging the judicious use of time and resources. Some of these methods have advanced past the exploratory research stage and are beginning to gain acceptance for the risk assessment of chemicals. A review of the recent literature reveals a burst of IVIVE publications over the past decade. In this review, we propose operational definitions for IVIVE, present literature examples for several common toxicity endpoints, and

SUBMITTER: Chang X 

PROVIDER: S-EPMC9143724 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature