Rapid Absorption of Naloxone from Eye Drops.

ABSTRACT: Naloxone as emergency treatment for opioid overdosing can be administered via several routes. However, the available administration methods are invasive or may be associated with incomplete or slow naloxone absorption. We evaluated pharmacokinetics and local tolerance of naloxone ocular drops in healthy beagle dogs. Naloxone administration as eye drops produced fast absorption with time to maximum plasma concentration (t_max) achieved in 14 to 28 min, high plasma exposure (C_max 10.3 ng/mL to 12.7 ng/mL), and good bioavailability (41% to 56%). No signs of ocular irritability were observed in the scored ocular tolerability parameters, and the reactions of dogs suggesting immediate ocular discomfort after the dosing were sporadic and short lasting. Slight and transient in

SUBMITTER: Tuunainen J 

PROVIDER: S-EPMC9143859 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature