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Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases.

ABSTRACT: Alzheimer's disease (AD), Parkinson's disease (PD), and Amyotrophic Lateral Sclerosis (ALS) are representative neurodegenerative diseases (NDs) characterized by degeneration of selective neurons, as well as the lack of effective biomarkers and therapeutic treatments. In the last decade, microRNAs (miRNAs) have gained considerable interest in diagnostics and therapy of NDs, owing to their aberrant expression and their ability to target multiple molecules and pathways. Here, we provide an overview of dysregulated miRNAs in fluids (blood or cerebrospinal fluid) and nervous tissue of AD, PD, and ALS patients. By emphasizing those that are commonly dysregulated in these NDs, we highlight their potential role as biomarkers or therapeutical targets and describe the use of antisense oligonucleotides as miRNA therapies.

SUBMITTER: Gentile G

PROVIDER: S-EPMC9143965 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases.

Gentile Giulia G Morello Giovanna G La Cognata Valentina V Guarnaccia Maria M Conforti Francesca Luisa FL Cavallaro Sebastiano S

Journal of personalized medicine 20220510 5

Alzheimer's disease (AD), Parkinson's disease (PD), and Amyotrophic Lateral Sclerosis (ALS) are representative neurodegenerative diseases (NDs) characterized by degeneration of selective neurons, as well as the lack of effective biomarkers and therapeutic treatments. In the last decade, microRNAs (miRNAs) have gained considerable interest in diagnostics and therapy of NDs, owing to their aberrant expression and their ability to target multiple molecules and pathways. Here, we provide an overview ...[more]

PMID: 35629192

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