Longitudinal changes of ADHD symptoms in association with white matter microstructure: A tract-specific fixel-based analysis.

ABSTRACT:

Background

Variation in the longitudinal course of childhood attention deficit/hyperactivity disorder (ADHD) coincides with neurodevelopmental maturation of brain structure and function. Prior work has attempted to determine how alterations in white matter (WM) relate to changes in symptom severity, but much of that work has been done in smaller cross-sectional samples using voxel-based analyses. Using standard diffusion-weighted imaging (DWI) methods, we previously showed WM alterations were associated with ADHD symptom remission over time in a longitudinal sample of probands, siblings, and unaffected individuals. Here, we extend this work by further assessing the nature of these changes in WM microstructure by including an additional follow-up measurement (aged 18 - 34 years), an

SUBMITTER: Damatac CG 

PROVIDER: S-EPMC9144034 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature