DVGfinder: A Metasearch Tool for Identifying Defective Viral Genomes in RNA-Seq Data.

ABSTRACT: The generation of different types of defective viral genomes (DVG) is an unavoidable consequence of the error-prone replication of RNA viruses. In recent years, a particular class of DVGs, those containing long deletions or genome rearrangements, has gain interest due to their potential therapeutic and biotechnological applications. Identifying such DVGs in high-throughput sequencing (HTS) data has become an interesting computational problem. Several algorithms have been proposed to accomplish this goal, though all incur false positives, a problem of practical interest if such DVGs have to be synthetized and tested in the laboratory. We present a metasearch tool, DVGfinder, that wraps the two most commonly used DVG search algorithms in a single workflow for the identification of the DVGs i

SUBMITTER: Olmo-Uceda MJ 

PROVIDER: S-EPMC9144107 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature