Synthesis and Antioxidant Activity of New Catechol Thioethers with the Methylene Linker.

ABSTRACT: Novel catechol thio-ethers with different heterocyclic substituents at sulfur atom were prepared by reacting 3,5-di-tert-butyl-6-methoxymethylcatechol with functionalized thiols under acidic conditions. A common feature of compounds is a methylene bridge between the catechol ring and thioether group. Two catechols with the thio-ether group, bound directly to the catechol ring, were also considered to assess the effect of the methylene linker on the antioxidant properties. The crystal structures of thio-ethers with benzo-thiazole moieties were established by single-crystal X-ray analysis. The radical scavenging and antioxidant activities were determined using 2,2'-diphenyl-1-picrylhydrazyl radical test, ABTS^∙+, CUPRAC (TEAC) assays, the reaction with superoxide radical ani

SUBMITTER: Smolyaninov IV 

PROVIDER: S-EPMC9144179 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature