Design and Synthesis of Novel Raman Reporters for Bioorthogonal SERS Nanoprobes Engineering.

ABSTRACT: Surface-enhanced Raman spectroscopy (SERS) exploiting Raman reporter-labeled nanoparticles (RR@NPs) represents a powerful tool for the improvement of optical bio-assays due to RRs' narrow peaks, SERS high sensitivity, and potential for multiplexing. In the present work, starting from low-cost and highly available raw materials such as cysteamine and substituted benzoic acids, novel bioorthogonal RRs, characterized by strong signal (10³ counts with FWHM < 15 cm^-1) in the biological Raman-silent region (>2000 cm^-1), RRs are synthesized by implementing a versatile, modular, and straightforward method with high yields and requiring three steps lasting 18 h, thus overcoming the limitations of current reported procedures. The resulting RRs' chemical structu

SUBMITTER: Dallari C 

PROVIDER: S-EPMC9144405 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature