Particle-Assisted Dermal Penetration-A Simple Formulation Strategy to Foster the Dermal Penetration Efficacy.

ABSTRACT: (1) Background: The study systematically investigated the influence of dispersed particles within a topical formulation on the dermal penetration efficacy of active compounds that are dissolved in the water phase of this formulation. The aim was to prove or disprove if particle-assisted dermal penetration can be used for improved dermal drug delivery. (2) Methods: Fluorescein was used as a surrogate for a hydrophilic active ingredient (AI). It was dissolved in the water phase of different formulations with and without particles. Two different types of particles (titanium dioxide and nanostructured lipid carriers (NLC)) were used. The influence of particle size and number of particles and the influence of skin hydrating excipients was also investigated. (3) Results demonstrate that the addi

SUBMITTER: Wiemann S 

PROVIDER: S-EPMC9144500 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature