In Vivo Efficacy of Amphotericin B against Four Candida auris Clades.

ABSTRACT: Candida auris is a multidrug-resistant fungus against which in some clinical situations amphotericin B (AMB) remains the alternative or first line drug. We compared daily 1 mg/kg of AMB efficacy in a neutropenic murine bloodstream infection model against 10 isolates representing four C. auris clades (South Asian n = 2; East Asian n = 2; South African n = 2; South American n = 4; two of which were of environmental origin). Five days of AMB treatment significantly increased the survival rates in mice infected with isolates of the East Asian clade, and 1 isolate each from the South African and South American clades (originated from bloodstream), but not in mice infected with the South Asian and 2 environmental isolates from the South American clades.

SUBMITTER: Forgacs L 

PROVIDER: S-EPMC9144575 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature