Antimicrobial Resistance and Virulence Characteristics of Klebsiella pneumoniae Isolates in Kenya by Whole-Genome Sequencing.

ABSTRACT: Klebsiella pneumoniae is a globally significant opportunistic pathogen causing healthcare-associated and community-acquired infections. This study examined the epidemiology and the distribution of resistance and virulence genes in clinical K. pneumoniae strains in Kenya. A total of 89 K. pneumoniae isolates were collected over six years from five counties in Kenya and were analyzed using whole-genome sequencing and bioinformatics. These isolates were obtained from community-acquired (62/89) and healthcare-associated infections (21/89), and from the hospital environment (6/89). Genetic analysis revealed the presence of bla_NDM-1 and bla_OXA-181 carbapenemase genes and the armA and rmtF genes known to confer pan-aminoglycos

SUBMITTER: Muraya A 

PROVIDER: S-EPMC9144577 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature