CAMDLES: CFD-DEM Simulation of Microbial Communities in Spaceflight and Artificial Microgravity.

ABSTRACT: We present CAMDLES (CFD-DEM Artificial Microgravity Developments for Living Ecosystem Simulation), an extension of CFDEM^®Coupling to model biological flows, growth, and mass transfer in artificial microgravity devices. For microbes that accompany humans into space, microgravity-induced alterations in the fluid environment are likely to be a major factor in the microbial experience of spaceflight. Computational modeling is needed to investigate how well ground-based microgravity simulation methods replicate that experience. CAMDLES incorporates agent-based modeling to study inter-species metabolite transport within microbial communities in rotating wall vessel bioreactors (RWVs). Preexisting CFD modeling of RWVs has not yet incorporated growth; CAMDLES employs the simultaneous mo

SUBMITTER: An R 

PROVIDER: S-EPMC9144607 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature