Biofabrication of Collagen Tissue-Engineered Blood Vessels with Direct Co-Axial Extrusion.

ABSTRACT: Cardiovascular diseases are considered one of the worldwide causes of death, with atherosclerosis being the most predominant. Nowadays, the gold standard treatment is blood vessel replacement by bypass surgery; however, autologous source is not always possible. Thereby, tissue-engineered blood vessels (TEBVs) are emerging as a potential alternative source. In terms of composition, collagen has been selected in many occasions to develop TEBVs as it is one of the main extracellular matrix components of arteries. However, it requires specific support or additional processing to maintain the tubular structure and appropriate mechanical properties. Here, we present a method to develop support-free collagen TEBVs with co-axial extrusion in a one-step procedure with high concentrated collagen. Th

SUBMITTER: Bosch-Rue E 

PROVIDER: S-EPMC9144639 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature