Leveraging Affinity Interactions to Prolong Drug Delivery of Protein Therapeutics.

ABSTRACT: While peptide and protein therapeutics have made tremendous advances in clinical treatments over the past few decades, they have been largely hindered by their ability to be effectively delivered to patients. While bolus parenteral injections have become standard clinical practice, they are insufficient to treat diseases that require sustained, local release of therapeutics. Cyclodextrin-based polymers (pCD) have been utilized as a platform to extend the local delivery of small-molecule hydrophobic drugs by leveraging hydrophobic-driven thermodynamic interactions between pCD and payload to extend its release, which has seen success both in vitro and in vivo. Herein, we proposed the novel synthesis of protein-polymer conjugates that are capped with a "high affinity" adamantane. Using bovine

SUBMITTER: Dogan AB 

PROVIDER: S-EPMC9144912 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature